RNA Details
Disease Name
myocardical ischemia
Tissue
heart
RNA Symbol
miR-218-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
dual-luciferase reporter assay;RNA pull-down assay
Target
NA
Pathway
NF-KAPPA B SIGNALING PATHWAY
PubMed ID
Title
Inhibition of miR-218-5p reduces myocardial ischemia-reperfusion injury in a Sprague-Dawley rat model by reducing oxidative stress and inflammation through MEF2C/NF-KB pathway
Year
2021
Function
"Inhibiting miR-218-5p declined lactate dehydrogenase activities and ROS, MDA and SOD levels in rat myocardial tissues under I/R injury, alleviated myocardial fibrosis and inflammatory reactions, and reduced myocardial infarction area."